Contact dermatitis treatment

Hair cleansing product tolerability study Részletes contact dermatitis treatment Study Aim: The objective of this study is to evaluate the tolerability of daily use of f hair cleansing products. A recent study of patients found no increase in hair loss when used in normal subjects, however skin assessments for tolerability were not evaluated. Methodology: This double-blind, randomized, controlled clinical trial will evaluate the tolerability of six hair cleansing products including Wen cleansing conditioner using two standard clinical and research methods, Repeat Open Application Tests ROAT a test for irritancy and Semi-Open Patch Tests a test for allergenicity.

For the ROAT, participants will apply the hair cleansing products to 6 separate locations on the forearm using a standardized, protocol and scored using a point scale. Application site of each cleansing product will be randomized. Exposure time will be increased in a step-wise fashion over 5 weeks.

Participants and investigators will be blinded to location of products. If intolerance to a specific product is reached, the ROAT for that product will be discontinued.

Clinical assessments global scoring and component scoring will be performed at 0, 2, and 4 and 5 weeks.

Primary outcomes will be measured at 5 weeks. To represent a broad spectrum of skin barrier function, recruitment will target enrollment of individuals with a no history of childhood eczema non-atopic and 50 individuals with a history of childhood eczema atopic.

Population: Men and women over the age of 18 years old. Átfogó állapot.